Identification and attenuation of physiological noise in fMRI using kernel techniques.


Journal Article (Review)

Functional magnetic resonance imaging (fMRI) techniques enable noninvasive studies of brain functional activity under task and resting states. However, the analysis of brain activity could be significantly affected by the cardiac- and respiration-induced physiological noise in fMRI data. In most multi-slice fMRI experiments, the temporal sampling rates are not high enough to critically sample the physiological noise, and the noise is aliased into frequency bands where useful brain functional signal exists, compromising the analysis. Most existing approaches cannot distinguish between the aliased noise and signal if they overlap in the frequency domain. In this work, we further developed a kernel principal component analysis based physiological removal method based on our previous work. Specifically, two kernel functions were evaluated based on a newly proposed criterion that can measure the capability of a kernel to separate the aliased physiological noise from fMRI signal. In addition, a mutual information based criterion was designed to select principal components for noise removal. The method was evaluated by human experimental fMRI studies, and the results demonstrate that the proposed method can effectively identify and attenuate the aliased physiological noise in fMRI data.

Full Text

Duke Authors

Cited Authors

  • Song, X; Chen, N-K; Gaur, P

Published Date

  • 2011

Published In

Volume / Issue

  • 2011 /

Start / End Page

  • 4852 - 4855

PubMed ID

  • 22255425

Pubmed Central ID

  • 22255425

International Standard Serial Number (ISSN)

  • 1557-170X

Digital Object Identifier (DOI)

  • 10.1109/IEMBS.2011.6091202


  • eng

Conference Location

  • United States