Guidelines for the use of tacrine in Alzheimer's disease: clinical application and effectiveness. Johns Hopkins Dementia Research Clinic.

Journal Article (Clinical Trial;Journal Article)

The efficacy of tacrine for treatment of Alzheimer's has been demonstrated in several clinical trials but has not been assessed in cases complicated by medical and psychiatric comorbidities. Additionally, the benefit-risk ratio of tacrine is small, so it is best administered with carefully developed guidelines that specify this ratio for patients and families. On the basis of guidelines developed for the Johns Hopkins Dementia Research Clinic, tacrine treatment was offered to 162 patients with probable Alzheimer's. Only 35 accepted, and only 22 continued on tacrine beyond 3 months. The latter group declined by 1.36 points over 1 year on the Mini-Mental State Examination, significantly less than expected. The authors conclude that, if used in the context of clinical guidelines, tacrine is an effective treatment for Alzheimer's.

Full Text

Duke Authors

Cited Authors

  • Lyketsos, CG; Corazzini, K; Steele, CD; Kraus, MF

Published Date

  • January 1996

Published In

Volume / Issue

  • 8 / 1

Start / End Page

  • 67 - 73

PubMed ID

  • 8845704

Electronic International Standard Serial Number (EISSN)

  • 1545-7222

International Standard Serial Number (ISSN)

  • 0895-0172

Digital Object Identifier (DOI)

  • 10.1176/jnp.8.1.67


  • eng