Ordered-subset analysis of savant skills in autism for 15q11-q13.

Journal Article (Journal Article)

Autism is a complex disorder characterized by genetic and phenotypic heterogeneity. Analysis of phenotypically homogeneous subtypes has been used to both confirm and narrow potential autism linkage regions such as the chromosomal region 15q11-q13. Increased evidence for linkage in this region had been found in a subgroup of 21 autism families (total families = 94) stratified based on a savant skill factor (SSF) from the Autism Diagnostic Interview, Revised (ADI-R). We examined the savant phenotypic finding in our sample of 91 multiplex autism families. Using two-point parametric analysis in stratification with a cutoff point of a savant skill score of 0.16, our families failed to demonstrate linkage to 15q11-q13. In addition, ordered subset analysis (OSA) using SSF as a covariate also failed to show evidence for linkage. Our findings do not support savant skills as an informative phenotypic subset for linkage in our sample.

Full Text

Duke Authors

Cited Authors

  • Ma, DQ; Jaworski, J; Menold, MM; Donnelly, S; Abramson, RK; Wright, HH; Delong, GR; Gilbert, JR; Pericak-Vance, MA; Cuccaro, ML

Published Date

  • May 5, 2005

Published In

Volume / Issue

  • 135B / 1

Start / End Page

  • 38 - 41

PubMed ID

  • 15756693

International Standard Serial Number (ISSN)

  • 1552-4841

Digital Object Identifier (DOI)

  • 10.1002/ajmg.b.30166


  • eng

Conference Location

  • United States