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Ordered-subset analysis of savant skills in autism for 15q11-q13.

Publication ,  Journal Article
Ma, DQ; Jaworski, J; Menold, MM; Donnelly, S; Abramson, RK; Wright, HH; Delong, GR; Gilbert, JR; Pericak-Vance, MA; Cuccaro, ML
Published in: Am J Med Genet B Neuropsychiatr Genet
May 5, 2005

Autism is a complex disorder characterized by genetic and phenotypic heterogeneity. Analysis of phenotypically homogeneous subtypes has been used to both confirm and narrow potential autism linkage regions such as the chromosomal region 15q11-q13. Increased evidence for linkage in this region had been found in a subgroup of 21 autism families (total families = 94) stratified based on a savant skill factor (SSF) from the Autism Diagnostic Interview, Revised (ADI-R). We examined the savant phenotypic finding in our sample of 91 multiplex autism families. Using two-point parametric analysis in stratification with a cutoff point of a savant skill score of 0.16, our families failed to demonstrate linkage to 15q11-q13. In addition, ordered subset analysis (OSA) using SSF as a covariate also failed to show evidence for linkage. Our findings do not support savant skills as an informative phenotypic subset for linkage in our sample.

Duke Scholars

Published In

Am J Med Genet B Neuropsychiatr Genet

DOI

ISSN

1552-4841

Publication Date

May 5, 2005

Volume

135B

Issue

1

Start / End Page

38 / 41

Location

United States

Related Subject Headings

  • Microsatellite Repeats
  • Male
  • Lod Score
  • Humans
  • Genotype
  • Genetic Linkage
  • Female
  • Family Health
  • Chromosomes, Human, Pair 15
  • Chromosome Mapping
 

Citation

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MLA
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Ma, D. Q., Jaworski, J., Menold, M. M., Donnelly, S., Abramson, R. K., Wright, H. H., … Cuccaro, M. L. (2005). Ordered-subset analysis of savant skills in autism for 15q11-q13. Am J Med Genet B Neuropsychiatr Genet, 135B(1), 38–41. https://doi.org/10.1002/ajmg.b.30166
Ma, D. Q., J. Jaworski, M. M. Menold, S. Donnelly, R. K. Abramson, H. H. Wright, G. R. Delong, J. R. Gilbert, M. A. Pericak-Vance, and Michael L. Cuccaro. “Ordered-subset analysis of savant skills in autism for 15q11-q13.Am J Med Genet B Neuropsychiatr Genet 135B, no. 1 (May 5, 2005): 38–41. https://doi.org/10.1002/ajmg.b.30166.
Ma DQ, Jaworski J, Menold MM, Donnelly S, Abramson RK, Wright HH, et al. Ordered-subset analysis of savant skills in autism for 15q11-q13. Am J Med Genet B Neuropsychiatr Genet. 2005 May 5;135B(1):38–41.
Ma, D. Q., et al. “Ordered-subset analysis of savant skills in autism for 15q11-q13.Am J Med Genet B Neuropsychiatr Genet, vol. 135B, no. 1, May 2005, pp. 38–41. Pubmed, doi:10.1002/ajmg.b.30166.
Ma DQ, Jaworski J, Menold MM, Donnelly S, Abramson RK, Wright HH, Delong GR, Gilbert JR, Pericak-Vance MA, Cuccaro ML. Ordered-subset analysis of savant skills in autism for 15q11-q13. Am J Med Genet B Neuropsychiatr Genet. 2005 May 5;135B(1):38–41.
Journal cover image

Published In

Am J Med Genet B Neuropsychiatr Genet

DOI

ISSN

1552-4841

Publication Date

May 5, 2005

Volume

135B

Issue

1

Start / End Page

38 / 41

Location

United States

Related Subject Headings

  • Microsatellite Repeats
  • Male
  • Lod Score
  • Humans
  • Genotype
  • Genetic Linkage
  • Female
  • Family Health
  • Chromosomes, Human, Pair 15
  • Chromosome Mapping