Comparison of two knowledge bases on the detection of drug-drug interactions.

Journal Article (Journal Article)

This paper describes a drug ordering decision support system that helps with the prevention of adverse drug events by detecting drug-drug interactions in drug orders. The architecture of the system was devised in order to facilitate its use attached to physician order entry systems. The described model focuses in issues related to knowledge base maintenance and integration with external systems. Finally, a retrospective study was performed. Two knowledge bases, developed by different academic centers, were used to detect drug-drug interactions in a dataset with 37,237 drug prescriptions. The study concludes that the proposed knowledge base architecture enables content from other knowledge sources to be easily transferred and adapted to its structure. The study also suggests a method that can be used on the evaluation and refinement of the content of drug knowledge bases.

Full Text

Duke Authors

Cited Authors

  • Del Fiol, G; Rocha, BH; Kuperman, GJ; Bates, DW; Nohama, P

Published Date

  • 2000

Published In

Start / End Page

  • 171 - 175

PubMed ID

  • 11079867

Pubmed Central ID

  • PMC2243877

International Standard Serial Number (ISSN)

  • 1531-605X


  • eng

Conference Location

  • United States