Drugs derived from cannabinoids. 4. Effect of alkyl substitution in sulfur and carbocyclic analogs.

Published

Journal Article

Various CNS-active cannabinoids in which the alicyclic ring was thiopheno, cyclopenteno, or cyclohexeno with the alkyl substituent in various positions (structural types 1-6) were synthesized by procedures described previously. These compounds were compared in selected pharmacological tests in mice, rats, dogs, and cats. The results suggested that methyl substitution in the close proximity of the phenolic hydroxyl group strongly influenced the activity of some cannabinoids, particularly of those which had a planar five-membered alicyclic ring rather than a six-membered ring.

Full Text

Duke Authors

Cited Authors

  • Razdan, RK; Handrick, GR; Dalzell, HC; Howes, JF; Winn, M; Plotnikoff, NP; Dodge, PW; Dren, AT

Published Date

  • April 1, 1976

Published In

Volume / Issue

  • 19 / 4

Start / End Page

  • 552 - 554

PubMed ID

  • 944269

Pubmed Central ID

  • 944269

Electronic International Standard Serial Number (EISSN)

  • 1520-4804

International Standard Serial Number (ISSN)

  • 0022-2623

Digital Object Identifier (DOI)

  • 10.1021/jm00226a023

Language

  • eng