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Diffusion-weighted hyperpolarized 129Xe MRI in healthy volunteers and subjects with chronic obstructive pulmonary disease.

Publication ,  Journal Article
Kaushik, SS; Cleveland, ZI; Cofer, GP; Metz, G; Beaver, D; Nouls, J; Kraft, M; Auffermann, W; Wolber, J; McAdams, HP; Driehuys, B
Published in: Magn Reson Med
April 2011

Given its greater availability and lower cost, (129) Xe apparent diffusion coefficient (ADC) MRI offers an alternative to (3) He ADC MRI. To demonstrate the feasibility of hyperpolarized (129) Xe ADC MRI, we present results from healthy volunteers (HV), chronic obstructive pulmonary disease (COPD) subjects, and age-matched healthy controls (AMC). The mean parenchymal ADC was 0.036 ± 0.003 cm(2) sec(-1) for HV, 0.043 ± 0.006 cm(2) sec(-1) for AMC, and 0.056 ± 0.008 cm(2) sec(-1) for COPD subjects with emphysema. In healthy individuals, but not the COPD group, ADC decreased significantly in the anterior-posterior direction by ∼ 22% (P = 0.006, AMC; 0.0059, HV), likely because of gravity-induced tissue compression. The COPD group exhibited a significantly larger superior-inferior ADC reduction (∼ 28%) than the healthy groups (∼ 24%) (P = 0.00018, HV; P = 3.45 × 10(-5) , AMC), consistent with smoking-related tissue destruction in the superior lung. Superior-inferior gradients in healthy subjects may result from regional differences in xenon concentration. ADC was significantly correlated with pulmonary function tests (forced expiratory volume in 1 sec, r = -0.77, P = 0.0002; forced expiratory volume in 1 sec/forced vital capacity, r = -0.77, P = 0.0002; diffusing capacity of carbon monoxide in the lung/alveolar volume (V(A) ), r = -0.77, P = 0.0002). In healthy groups, ADC increased with age by 0.0002 cm(2) sec(-1) year(-1) (r = 0.56, P = 0.02). This study shows that (129) Xe ADC MRI is clinically feasible, sufficiently sensitive to distinguish HV from subjects with emphysema, and detects age- and posture-dependent changes.

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Published In

Magn Reson Med

DOI

EISSN

1522-2594

Publication Date

April 2011

Volume

65

Issue

4

Start / End Page

1154 / 1165

Location

United States

Related Subject Headings

  • Xenon Isotopes
  • Sensitivity and Specificity
  • Reproducibility of Results
  • Reference Values
  • Radiopharmaceuticals
  • Pulmonary Disease, Chronic Obstructive
  • Nuclear Medicine & Medical Imaging
  • Middle Aged
  • Male
  • Lung
 

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Kaushik, S. S., Cleveland, Z. I., Cofer, G. P., Metz, G., Beaver, D., Nouls, J., … Driehuys, B. (2011). Diffusion-weighted hyperpolarized 129Xe MRI in healthy volunteers and subjects with chronic obstructive pulmonary disease. Magn Reson Med, 65(4), 1154–1165. https://doi.org/10.1002/mrm.22697
Kaushik, S Sivaram, Zackary I. Cleveland, Gary P. Cofer, Gregory Metz, Denise Beaver, John Nouls, Monica Kraft, et al. “Diffusion-weighted hyperpolarized 129Xe MRI in healthy volunteers and subjects with chronic obstructive pulmonary disease.Magn Reson Med 65, no. 4 (April 2011): 1154–65. https://doi.org/10.1002/mrm.22697.
Kaushik SS, Cleveland ZI, Cofer GP, Metz G, Beaver D, Nouls J, et al. Diffusion-weighted hyperpolarized 129Xe MRI in healthy volunteers and subjects with chronic obstructive pulmonary disease. Magn Reson Med. 2011 Apr;65(4):1154–65.
Kaushik, S. Sivaram, et al. “Diffusion-weighted hyperpolarized 129Xe MRI in healthy volunteers and subjects with chronic obstructive pulmonary disease.Magn Reson Med, vol. 65, no. 4, Apr. 2011, pp. 1154–65. Pubmed, doi:10.1002/mrm.22697.
Kaushik SS, Cleveland ZI, Cofer GP, Metz G, Beaver D, Nouls J, Kraft M, Auffermann W, Wolber J, McAdams HP, Driehuys B. Diffusion-weighted hyperpolarized 129Xe MRI in healthy volunteers and subjects with chronic obstructive pulmonary disease. Magn Reson Med. 2011 Apr;65(4):1154–1165.
Journal cover image

Published In

Magn Reson Med

DOI

EISSN

1522-2594

Publication Date

April 2011

Volume

65

Issue

4

Start / End Page

1154 / 1165

Location

United States

Related Subject Headings

  • Xenon Isotopes
  • Sensitivity and Specificity
  • Reproducibility of Results
  • Reference Values
  • Radiopharmaceuticals
  • Pulmonary Disease, Chronic Obstructive
  • Nuclear Medicine & Medical Imaging
  • Middle Aged
  • Male
  • Lung