The contribution of autophagy to lymphocyte survival and homeostasis.

Published

Journal Article (Review)

Over the life span of a T lymphocyte, from thymic development to death, it is subjected to a variety of stresses and stimuli. Upon receipt of each stress or stimulus, a potentially life-changing fate decision must be made, namely, whether to commit to a form of programmed cell death or to make the necessary adaptations to effectively deal with the changing environment. In our laboratory, we have identified several stresses that a T lymphocyte will encounter during a normal life span. Our studies have focused on how T cells utilize autophagy to get a grasp on the situation, or in cases in which survival is untenable, how T cells use autophagy to hasten their demise. This review focuses on the functions of T-cell autophagy in maintaining homeostasis, eliminating excess or dangerous levels of mitochondria, trimming levels of endoplasmic reticulum, and promoting a healthy metabolic level to allow cells to perform as productive components of the immune system. In addition, the use of autophagy signaling molecules to perform autophagy-independent tasks involved in the maintenance of immune homeostasis is discussed.

Full Text

Duke Authors

Cited Authors

  • McLeod, IX; Jia, W; He, Y-W

Published Date

  • September 2012

Published In

Volume / Issue

  • 249 / 1

Start / End Page

  • 195 - 204

PubMed ID

  • 22889223

Pubmed Central ID

  • 22889223

Electronic International Standard Serial Number (EISSN)

  • 1600-065X

International Standard Serial Number (ISSN)

  • 0105-2896

Digital Object Identifier (DOI)

  • 10.1111/j.1600-065X.2012.01143.x

Language

  • eng