The TGF-beta-related DVR gene family in mammalian development.
Journal Article (Journal Article;Review)
The genes that encode the bone morphogenetic proteins and the Vg-related proteins are mammalian members of a group of TGF-beta-related genes, designated the DVR family, that includes the decapentaplegic gene of Drosophila and the Vg1 gene of Xenopus. Members of the DVR (decapentaplegic-Vg-related) family have been implicated in diverse processes during development, particularly in epithelial-mesenchymal interactions. The results of our in situ hybridization studies with postimplantation mouse embryos provide evidence for the involvement of DVR family members, particularly DVR-2, DVR-4 and DVR-6, in specific inductive interactions during the development of many organs, including the limb, the whisker follicle and the heart.
Full Text
Duke Authors
Cited Authors
- Lyons, KM; Jones, CM; Hogan, BL
Published Date
- 1992
Published In
Volume / Issue
- 165 /
Start / End Page
- 219 - 230
PubMed ID
- 1516470
International Standard Serial Number (ISSN)
- 0300-5208
Digital Object Identifier (DOI)
- 10.1002/9780470514221.ch13
Language
- eng
Conference Location
- Netherlands