Trichodysplasia spinulosa--a newly described folliculocentric viral infection in an immunocompromised host.

Journal Article (Journal Article)

This is a case report of an immunocompromised individual who presented with progressive alopecia, friable follicular spinous processes, and erythematous, indurated papules. Examination of skin biopsies using light microscopy and immunohistochemistry revealed pathologic changes of the follicular inner root sheath epithelium with dystrophic trichohyaline granules. Electron microscopy of thin sections of tissue revealed intracellular viral particles with a size and appearance consistent with those in the Papovaviridae family. Electron microscopy of negatively stained extract from a homogenized lesion also demonstrated icosahedral viruses with papovavirus morphology. We believe this is a previously unreported folliculocentric viral infection in an immunosuppressed human host and have termed this entity "trichodysplasia spinulosa".

Full Text

Duke Authors

Cited Authors

  • Haycox, CL; Kim, S; Fleckman, P; Smith, LT; Piepkorn, M; Sundberg, JP; Howell, DN; Miller, SE

Published Date

  • December 1999

Published In

Volume / Issue

  • 4 / 3

Start / End Page

  • 268 - 271

PubMed ID

  • 10674379

International Standard Serial Number (ISSN)

  • 1087-0024

Digital Object Identifier (DOI)

  • 10.1038/sj.jidsp.5640227


  • eng

Conference Location

  • United States