Variability of action potential duration in pharmacologically induced long QT syndrome type 1.

Journal Article (Journal Article)

Long QT Syndrome (LQTS) is a congenital disorder associated with life-threatening arrhythmias. LQT1, a type of LQTS affecting the slow delayed rectifier potassium current, shows a higher incidence of arrhythmia associated with sympathetic stimulation than other types of LQTS. LQT1 patients show increased variability of repolarization with epinephrine infusion, as measured from the 12-lead ECG. We investigate the variability of repolarization measured as action potential duration (APD) in the rabbit left ventricle: how APD variability is affected by pacing rate, transmural location, LQT1 induced by chromanol 293b, and epinephrine infusion. Chromanol preferentially changes APD variability in the midwall. Infusing epinephrine returns the variability to near-control levels. These results differ substantially from clinical studies and show the need for further study.

Full Text

Duke Authors

Cited Authors

  • Ring, CL; Idriss, SF; Neu, WK

Published Date

  • 2009

Published In

  • Annu Int Conf Ieee Eng Med Biol Soc

Volume / Issue

  • 2009 /

Start / End Page

  • 4520 - 4522

PubMed ID

  • 19964641

Pubmed Central ID

  • PMC4288588

International Standard Serial Number (ISSN)

  • 2375-7477

Digital Object Identifier (DOI)

  • 10.1109/IEMBS.2009.5334105


  • eng

Conference Location

  • United States