ApolipoproteinE mimetic peptides improve outcome after focal ischemia.

Published

Journal Article

Growing clinical evidence implicates isoform-specific effects of apolipoprotein E (apoE) in reducing neuroinflammation and mediating adaptive responses following ischemic and traumatic brain injury. However, the intact apoE holoprotein does not cross the blood-brain barrier and thus has limited therapeutic potential. We have created a small peptide, COG1410 (acetyl-AS-Aib-LRKL-Aib-KRLL-amide), derived from the apoE receptor-binding region. COG1410 retains the anti-inflammatory and neuroprotective biological properties of the intact holoprotein and penetrates the blood-brain barrier. In the current study, we utilized a murine model of transient focal cerebral ischemia and reperfusion to demonstrate that intravenous (IV) administration of COG1410 reduces infarct volume and radiographic progression of infarct, and improves functional outcome as assessed by rotarod when delivered up to 4h after ischemia onset.

Full Text

Duke Authors

Cited Authors

  • Wang, H; Anderson, LG; Lascola, CD; James, ML; Venkatraman, TN; Bennett, ER; Acheson, SK; Vitek, MP; Laskowitz, DT

Published Date

  • March 2013

Published In

Volume / Issue

  • 241 /

Start / End Page

  • 67 - 74

PubMed ID

  • 23219883

Pubmed Central ID

  • 23219883

Electronic International Standard Serial Number (EISSN)

  • 1090-2430

Digital Object Identifier (DOI)

  • 10.1016/j.expneurol.2012.11.027

Language

  • eng

Conference Location

  • United States