Evaluation of the PharmGKB knowledge base as a resource for efficiently assessing the clinical validity and utility of pharmacogenetic assays.

Published online

Journal Article

Prior to clinical use, pharmacogenetic tests should be systematically evaluated for their clinical validity and utility. Here, we evaluated whether the publicly available, online Pharmacogenomics Knowledge Base (PharmGKB) could facilitate such assessments by efficiently identifying relevant peer-reviewed manuscripts. The search targets were 55 manuscripts regarding clinical validity and utility included in systematic reviews of warfarin, antidepressant, and irinotecan pharmacogenetics. When direct inclusion in PharmGKB was the search criterion, recall was 33% and precision was 16%. However, recall increased to 78% when citation within a PharmGKB-identified manuscript was added as a search criterion. These recalled manuscripts accounted for 87% of the study subjects, and domain experts determined that the omission of the remaining manuscripts was unlikely to have changed the conclusions of the reviews. Thus, we conclude that PharmGKB can facilitate the systematic assessment of pharmacogenetic assays through the efficient identification of relevant peer-reviewed manuscripts.

Full Text

Duke Authors

Cited Authors

  • Kawamoto, K; Orlando, LA; Voora, D; Lobach, DF; Joy, S; Cho, A; Ginsburg, GS

Published Date

  • November 14, 2009

Published In

Volume / Issue

  • 2009 /

Start / End Page

  • 307 - 311

PubMed ID

  • 20351870

Pubmed Central ID

  • 20351870

Electronic International Standard Serial Number (EISSN)

  • 1942-597X

Language

  • eng

Conference Location

  • United States