Mouse models of human non-small-cell lung cancer: raising the bar.

Journal Article (Journal Article;Review)

Lung cancer is a devastating disease that presents a challenge to basic research to provide new steps toward therapeutic advances. The cell-type-specific responses to oncogenic mutations that initiate and regulate lung cancer remain poorly defined. A better understanding of the relevant signaling pathways and mechanisms that control therapeutic outcome could also provide new insight. Improved conditional mouse models are now available as tools to improve the understanding of the cellular and molecular origins of adenocarcinoma. These models have already proven their utility in proof-of-principle experiments with new technologies including genomics and imaging. Integrated thinking to apply technological advances while using the appropriate mouse model is likely to facilitate discoveries that will significantly improve lung cancer detection and intervention.

Full Text

Duke Authors

Cited Authors

  • Kim, CFB; Jackson, EL; Kirsch, DG; Grimm, J; Shaw, AT; Lane, K; Kissil, J; Olive, KP; Sweet-Cordero, A; Weissleder, R; Jacks, T

Published Date

  • 2005

Published In

Volume / Issue

  • 70 /

Start / End Page

  • 241 - 250

PubMed ID

  • 16869760

International Standard Serial Number (ISSN)

  • 0091-7451

Digital Object Identifier (DOI)

  • 10.1101/sqb.2005.70.037


  • eng

Conference Location

  • United States