Focal not widespread grafts induce novel dyskinetic behavior in parkinsonian rats.
Journal Article (Journal Article)
Dyskinesias are a common consequence of dopaminergic therapy in patients with Parkinson's disease. Little is known about the influence of cellular replacement strategies upon drug-induced dyskinesias. In the current study, we employed parkinsonian rats to test whether the distribution of dopamine neuron grafts could differentially alter striatal circuitry and levodopa-induced dyskinesias. Specifically, we compared behavioral and neurochemical consequences of dopamine reinnervation restricted to a focal region of the striatum to innervation encompassing the majority of the striatum by distributing the same number of cells into single locus or multiple locations. Both the single-site and widespread grafts reduced pregraft dyskinesias and normalized FosB/DeltaFosB in the dorsal two-thirds of the lateral striatum. However, single-site DA graft recipients developed a robust, novel forelimb-facial stereotypy and upregulated FosB/DeltaFosB expression in the ventrolateral striatum, an area associated with movements of tongue and forelimbs. The onset of forelimb-facial stereotypy correlated with measures of increased graft function.
Full Text
Duke Authors
Cited Authors
- Maries, E; Kordower, JH; Chu, Y; Collier, TJ; Sortwell, CE; Olaru, E; Shannon, K; Steece-Collier, K
Published Date
- January 2006
Published In
Volume / Issue
- 21 / 1
Start / End Page
- 165 - 180
PubMed ID
- 16095907
Pubmed Central ID
- 16095907
International Standard Serial Number (ISSN)
- 0969-9961
Digital Object Identifier (DOI)
- 10.1016/j.nbd.2005.07.002
Language
- eng
Conference Location
- United States