Focal not widespread grafts induce novel dyskinetic behavior in parkinsonian rats.

Published

Journal Article

Dyskinesias are a common consequence of dopaminergic therapy in patients with Parkinson's disease. Little is known about the influence of cellular replacement strategies upon drug-induced dyskinesias. In the current study, we employed parkinsonian rats to test whether the distribution of dopamine neuron grafts could differentially alter striatal circuitry and levodopa-induced dyskinesias. Specifically, we compared behavioral and neurochemical consequences of dopamine reinnervation restricted to a focal region of the striatum to innervation encompassing the majority of the striatum by distributing the same number of cells into single locus or multiple locations. Both the single-site and widespread grafts reduced pregraft dyskinesias and normalized FosB/DeltaFosB in the dorsal two-thirds of the lateral striatum. However, single-site DA graft recipients developed a robust, novel forelimb-facial stereotypy and upregulated FosB/DeltaFosB expression in the ventrolateral striatum, an area associated with movements of tongue and forelimbs. The onset of forelimb-facial stereotypy correlated with measures of increased graft function.

Full Text

Duke Authors

Cited Authors

  • Maries, E; Kordower, JH; Chu, Y; Collier, TJ; Sortwell, CE; Olaru, E; Shannon, K; Steece-Collier, K

Published Date

  • January 2006

Published In

Volume / Issue

  • 21 / 1

Start / End Page

  • 165 - 180

PubMed ID

  • 16095907

Pubmed Central ID

  • 16095907

International Standard Serial Number (ISSN)

  • 0969-9961

Digital Object Identifier (DOI)

  • 10.1016/j.nbd.2005.07.002

Language

  • eng

Conference Location

  • United States