Wnt-signaling in retinal development and disease.

Journal Article (Journal Article;Review)

The Wnt-signaling pathway is a known regulator of stem cell maintenance, cellular proliferation and differentiation, and cancer development in various tissues. Wnt proteins play a central role during various stages of retinal development; retinal field establishment, retinal and hyaloid vasculogenesis, cornea and lens development, eye field formation, and maintenance of retinal stem cell and neuronal specification in many species are Wnt-regulated processes. Uncontrolled Wnt signaling may cause retinal diseases such as familial exudative vitroretinopathy, retinitis pigmentosa, and Norrie's disease, further underscoring the importance of the Wnt-signaling pathway in the retina. This review summarizes major developments and discoveries regarding the role of the Wnt-signaling pathway as it pertains to retinal development and disease.

Full Text

Duke Authors

Cited Authors

  • Lad, EM; Cheshier, SH; Kalani, MYS

Published Date

  • 2009

Published In

Volume / Issue

  • 18 / 1

Start / End Page

  • 7 - 16

PubMed ID

  • 18690791

Electronic International Standard Serial Number (EISSN)

  • 1557-8534

Digital Object Identifier (DOI)

  • 10.1089/scd.2008.0169


  • eng

Conference Location

  • United States