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Intravitreal injection of therapeutic agents.

Publication ,  Journal Article
Peyman, GA; Lad, EM; Moshfeghi, DM
Published in: Retina
2009

BACKGROUND: Intravitreal injection (IVI) with administration of various pharmacological agents is a mainstay of treatment in ophthalmology for endopthalmitis, viral retinitis, age-related macular degeneration, cystoid macular edema, diabetic retinopathy, uveitis, vascular occlusions, and retinal detachment. The indications and therapeutic agents are reviewed in this study. METHODS: A search of the English, German, and Spanish language MEDLINE database was conducted. A total of 654 references spanning the period through early 2008 were individually evaluated. RESULTS: The advantage of the IVI technique is the ability to maximize intraocular levels of medications and to avoid the toxicities associated with systemic treatment. Intravitreal injection has been used to deliver several types of pharmacological agents into the vitreous cavity: antiinfective and antiinflammatory medications, immunomodulators, anticancer agents, gas, antivascular endothelial growth factor, and several others. The goal of this review is to provide a detailed description of the properties of numerous therapeutic agents that can be delivered through IVI, potential complications of the technique, and recommendations to avoid side effects. CONCLUSION: The IVI technique is a valuable tool that can be tailored to the disease process of interest based on the pharmacological agent selected. This review provides the reader with a comprehensive summary of the IVI technique and its multitude of uses.

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Published In

Retina

DOI

EISSN

1539-2864

Publication Date

2009

Volume

29

Issue

7

Start / End Page

875 / 912

Location

United States

Related Subject Headings

  • Vitreous Body
  • Ophthalmology & Optometry
  • Injections
  • Humans
  • Drug Therapy
  • 3212 Ophthalmology and optometry
  • 1113 Opthalmology and Optometry
 

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Peyman, G. A., Lad, E. M., & Moshfeghi, D. M. (2009). Intravitreal injection of therapeutic agents. Retina, 29(7), 875–912. https://doi.org/10.1097/IAE.0b013e3181a94f01
Peyman, Gholam A., Eleonora M. Lad, and Darius M. Moshfeghi. “Intravitreal injection of therapeutic agents.Retina 29, no. 7 (2009): 875–912. https://doi.org/10.1097/IAE.0b013e3181a94f01.
Peyman GA, Lad EM, Moshfeghi DM. Intravitreal injection of therapeutic agents. Retina. 2009;29(7):875–912.
Peyman, Gholam A., et al. “Intravitreal injection of therapeutic agents.Retina, vol. 29, no. 7, 2009, pp. 875–912. Pubmed, doi:10.1097/IAE.0b013e3181a94f01.
Peyman GA, Lad EM, Moshfeghi DM. Intravitreal injection of therapeutic agents. Retina. 2009;29(7):875–912.

Published In

Retina

DOI

EISSN

1539-2864

Publication Date

2009

Volume

29

Issue

7

Start / End Page

875 / 912

Location

United States

Related Subject Headings

  • Vitreous Body
  • Ophthalmology & Optometry
  • Injections
  • Humans
  • Drug Therapy
  • 3212 Ophthalmology and optometry
  • 1113 Opthalmology and Optometry