The Ocular Hypertension Treatment Study: baseline factors that predict the onset of primary open-angle glaucoma.

Published

Journal Article

BACKGROUND: The Ocular Hypertension Treatment Study (OHTS) has shown that topical ocular hypotensive medication is effective in delaying or preventing the onset of primary open-angle glaucoma (POAG) in individuals with elevated intraocular pressure (ocular hypertension) and no evidence of glaucomatous damage. OBJECTIVE: To describe baseline demographic and clinical factors that predict which participants in the OHTS developed POAG. METHODS: Baseline demographic and clinical data were collected prior to randomization except for corneal thickness measurements, which were performed during follow-up. Proportional hazards models were used to identify factors that predicted which participants in the OHTS developed POAG. RESULTS: In univariate analyses, baseline factors that predicted the development of POAG included older age, race (African American), sex (male), larger vertical cup-disc ratio, larger horizontal cup-disc ratio, higher intraocular pressure, greater Humphrey visual field pattern standard deviation, heart disease, and thinner central corneal measurement. In multivariate analyses, baseline factors that predicted the development of POAG included older age, larger vertical or horizontal cup-disc ratio, higher intraocular pressure, greater pattern standard deviation, and thinner central corneal measurement. CONCLUSIONS: Baseline age, vertical and horizontal cup-disc ratio, pattern standard deviation, and intraocular pressure were good predictors for the onset of POAG in the OHTS. Central corneal thickness was found to be a powerful predictor for the development of POAG.

Full Text

Cited Authors

  • Gordon, MO; Beiser, JA; Brandt, JD; Heuer, DK; Higginbotham, EJ; Johnson, CA; Keltner, JL; Miller, JP; Parrish, RK; Wilson, MR; Kass, MA

Duke Contributors

Published Date

  • June 2002

Published In

Volume / Issue

  • 120 / 6

Start / End Page

  • 714 - 720

PubMed ID

  • 12049575

Pubmed Central ID

  • 12049575

International Standard Serial Number (ISSN)

  • 0003-9950

Digital Object Identifier (DOI)

  • 10.1001/archopht.120.6.714

Language

  • eng

Conference Location

  • United States