Nonreceptor tyrosine kinase BMX maintains self-renewal and tumorigenic potential of glioblastoma stem cells by activating STAT3.
Journal Article (Journal Article)
Glioblastomas display cellular hierarchies containing tumor-propagating glioblastoma stem cells (GSCs). STAT3 is a critical signaling node in GSC maintenance but molecular mechanisms underlying STAT3 activation in GSCs are poorly defined. Here we demonstrate that the bone marrow X-linked (BMX) nonreceptor tyrosine kinase activates STAT3 signaling to maintain self-renewal and tumorigenic potential of GSCs. BMX is differentially expressed in GSCs relative to nonstem cancer cells and neural progenitors. BMX knockdown potently inhibited STAT3 activation, expression of GSC transcription factors, and growth of GSC-derived intracranial tumors. Constitutively active STAT3 rescued the effects of BMX downregulation, supporting that BMX signals through STAT3 in GSCs. These data demonstrate that BMX represents a GSC therapeutic target and reinforces the importance of STAT3 signaling in stem-like cancer phenotypes.
Full Text
Duke Authors
Cited Authors
- Guryanova, OA; Wu, Q; Cheng, L; Lathia, JD; Huang, Z; Yang, J; MacSwords, J; Eyler, CE; McLendon, RE; Heddleston, JM; Shou, W; Hambardzumyan, D; Lee, J; Hjelmeland, AB; Sloan, AE; Bredel, M; Stark, GR; Rich, JN; Bao, S
Published Date
- April 12, 2011
Published In
Volume / Issue
- 19 / 4
Start / End Page
- 498 - 511
PubMed ID
- 21481791
Pubmed Central ID
- PMC3076106
Electronic International Standard Serial Number (EISSN)
- 1878-3686
Digital Object Identifier (DOI)
- 10.1016/j.ccr.2011.03.004
Language
- eng
Conference Location
- United States