Mutations in CIC and FUBP1 contribute to human oligodendroglioma.

Published

Journal Article

Oligodendrogliomas are the second most common malignant brain tumor in adults and exhibit characteristic losses of chromosomes 1p and 19q. To identify the molecular genetic basis for this alteration, we performed exomic sequencing of seven tumors. Among other changes, we found that the CIC gene (homolog of the Drosophila gene capicua) on chromosome 19q was somatically mutated in six cases and that the FUBP1 gene [encoding far-upstream element (FUSE) binding protein] on chromosome 1p was somatically mutated in two tumors. Examination of 27 additional oligodendrogliomas revealed 12 and 3 more tumors with mutations of CIC and FUBP1, respectively, 58% of which were predicted to result in truncations of the encoded proteins. These results suggest a critical role for these genes in the biology and pathology of oligodendrocytes.

Full Text

Duke Authors

Cited Authors

  • Bettegowda, C; Agrawal, N; Jiao, Y; Sausen, M; Wood, LD; Hruban, RH; Rodriguez, FJ; Cahill, DP; McLendon, R; Riggins, G; Velculescu, VE; Oba-Shinjo, SM; Marie, SKN; Vogelstein, B; Bigner, D; Yan, H; Papadopoulos, N; Kinzler, KW

Published Date

  • September 9, 2011

Published In

Volume / Issue

  • 333 / 6048

Start / End Page

  • 1453 - 1455

PubMed ID

  • 21817013

Pubmed Central ID

  • 21817013

Electronic International Standard Serial Number (EISSN)

  • 1095-9203

Digital Object Identifier (DOI)

  • 10.1126/science.1210557

Language

  • eng

Conference Location

  • United States