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Stochastic segment models of eukaryotic promoter regions.

Publication ,  Journal Article
Ohler, U; Stemmer, G; Harbeck, S; Niemann, H
Published in: Pac Symp Biocomput
2000

We present a new statistical approach for eukaryotic polymerase II promoter recognition. We apply stochastic segment models in which each state represents a functional part of the promoter. The segments are trained in an unsupervised way. We compare segment models with three and five states with our previous system which modeled the promoters as a whole, i.e. as a single state. Results on the classification of a representative collection of human and D. melanogaster promoter and non-promoter sequences show great improvements. The practical importance is demonstrated on the mining of large contiguous sequences.

Duke Scholars

Published In

Pac Symp Biocomput

DOI

ISSN

2335-6928

Publication Date

2000

Start / End Page

380 / 391

Location

United States

Related Subject Headings

  • Stochastic Processes
  • Promoter Regions, Genetic
  • Models, Genetic
  • Humans
  • Genome
  • Drosophila melanogaster
  • Databases, Factual
  • DNA Polymerase II
  • Computer Simulation
  • Animals
 

Citation

APA
Chicago
ICMJE
MLA
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Ohler, U., Stemmer, G., Harbeck, S., & Niemann, H. (2000). Stochastic segment models of eukaryotic promoter regions. Pac Symp Biocomput, 380–391. https://doi.org/10.1142/9789814447331_0036
Ohler, U., G. Stemmer, S. Harbeck, and H. Niemann. “Stochastic segment models of eukaryotic promoter regions.Pac Symp Biocomput, 2000, 380–91. https://doi.org/10.1142/9789814447331_0036.
Ohler U, Stemmer G, Harbeck S, Niemann H. Stochastic segment models of eukaryotic promoter regions. Pac Symp Biocomput. 2000;380–91.
Ohler, U., et al. “Stochastic segment models of eukaryotic promoter regions.Pac Symp Biocomput, 2000, pp. 380–91. Pubmed, doi:10.1142/9789814447331_0036.
Ohler U, Stemmer G, Harbeck S, Niemann H. Stochastic segment models of eukaryotic promoter regions. Pac Symp Biocomput. 2000;380–391.

Published In

Pac Symp Biocomput

DOI

ISSN

2335-6928

Publication Date

2000

Start / End Page

380 / 391

Location

United States

Related Subject Headings

  • Stochastic Processes
  • Promoter Regions, Genetic
  • Models, Genetic
  • Humans
  • Genome
  • Drosophila melanogaster
  • Databases, Factual
  • DNA Polymerase II
  • Computer Simulation
  • Animals