Vascular health, diabetes, APOE and dementia: the Aging, Demographics, and Memory Study.

Published online

Journal Article

INTRODUCTION: Evidence from clinical samples and geographically limited population studies suggests that vascular health, diabetes and apolipoprotein epsilon4 (APOE) are associated with dementia. METHODS: A population-based sample of 856 individuals aged 71 years or older from all contiguous regions of the United States received an extensive in-home clinical and neuropsychological assessment in 2001-2003. The relation of hypertension, diabetes, heart disease, stroke, medication usage, and APOE epsilon4 to dementia was modelled using adjusted multivariable logistic regression. RESULTS: Treated stroke (odds ratio [OR] 3.8, 95% confidence interval [CI] 2.0, 7.2), untreated stroke (OR 3.5, 95% CI 1.7, 7.3), and APOE epsilon4 (OR 2.8, 95% CI 1.7, 4.5) all increased the odds of dementia. Treated hypertension was associated with lower odds of dementia (OR 0.5, 95% CI 0.3, 1.0). Diabetes and heart disease were not significantly associated with dementia. A significant interaction was observed between APOE epsilon4 and stroke (P = 0.001). CONCLUSIONS: Data from the first dementia study that is representative of the United States population suggest that stroke, the APOE epsilon4 allele and their interaction are strongly associated with dementia.

Full Text

Duke Authors

Cited Authors

  • Llewellyn, DJ; Lang, IA; Matthews, FE; Plassman, BL; Rogers, MA; Morgenstern, LB; Fisher, GG; Kabeto, MU; Langa, KM

Published Date

  • June 24, 2010

Published In

Volume / Issue

  • 2 / 3

Start / End Page

  • 19 -

PubMed ID

  • 20576093

Pubmed Central ID

  • 20576093

Electronic International Standard Serial Number (EISSN)

  • 1758-9193

Digital Object Identifier (DOI)

  • 10.1186/alzrt43


  • eng

Conference Location

  • England