Apolipoprotein E epsilon 4 allele and hippocampal volume in twins with normal cognition.


Journal Article

We examined the relation of APOE-epsilon 4, hippocampal volume, and cognitive performance in ten pairs of cognitively normal twins who had a mean age of 62.5 years (SD = 7.8). There were no significant differences in neuropsychological measures of the groups categorized by the presence of an epsilon 4 allele. However, the mean normalized right and left hippocampal volumes were smaller in the epsilon 4 groups compared to the group without epsilon 4. Combined with prior reports, these findings suggest that epsilon 4 is associated with differences in brain morphology that may be evident when no symptoms of dementia are present.

Full Text

Duke Authors

Cited Authors

  • Plassman, BL; Welsh-Bohmer, KA; Bigler, ED; Johnson, SC; Anderson, CV; Helms, MJ; Saunders, AM; Breitner, JC

Published Date

  • April 1997

Published In

Volume / Issue

  • 48 / 4

Start / End Page

  • 985 - 989

PubMed ID

  • 9109888

Pubmed Central ID

  • 9109888

International Standard Serial Number (ISSN)

  • 0028-3878

Digital Object Identifier (DOI)

  • 10.1212/wnl.48.4.985


  • eng

Conference Location

  • United States