Apolipoprotein E epsilon 4 allele and hippocampal volume in twins with normal cognition.
Published
Journal Article
We examined the relation of APOE-epsilon 4, hippocampal volume, and cognitive performance in ten pairs of cognitively normal twins who had a mean age of 62.5 years (SD = 7.8). There were no significant differences in neuropsychological measures of the groups categorized by the presence of an epsilon 4 allele. However, the mean normalized right and left hippocampal volumes were smaller in the epsilon 4 groups compared to the group without epsilon 4. Combined with prior reports, these findings suggest that epsilon 4 is associated with differences in brain morphology that may be evident when no symptoms of dementia are present.
Full Text
Duke Authors
Cited Authors
- Plassman, BL; Welsh-Bohmer, KA; Bigler, ED; Johnson, SC; Anderson, CV; Helms, MJ; Saunders, AM; Breitner, JC
Published Date
- April 1997
Published In
Volume / Issue
- 48 / 4
Start / End Page
- 985 - 989
PubMed ID
- 9109888
Pubmed Central ID
- 9109888
International Standard Serial Number (ISSN)
- 0028-3878
Digital Object Identifier (DOI)
- 10.1212/wnl.48.4.985
Language
- eng
Conference Location
- United States