This article describes 10 special therapeutic tubes utilized in gastroenterology. The discussion includes a description of each tube; categories are developed by anatomical site as well as the number of lumens in each tube. Several tubes are not discussed due to previous development in the literature or specialty purposes limited to diagnostics: esophageal manometry, Levin, Salem sump, gastrostomy tubes, bougies, dilators, the Dreiling tube and the Rubin-Quinton tube. Many of the tubes discussed are often utilized in the inpatient setting on a ward and may not be as familiar to the gastroenterology nurse or associate in an endoscopy suite.