Effect of early and late GB virus C viraemia on survival of HIV-infected individuals: a meta-analysis.


Journal Article

OBJECTIVES: To conduct a meta-analysis to synthesize the evidence regarding the effect of co-infection with GB virus C (GBV-C) on survival of HIV-infected individuals, and to estimate the effect. METHODS: A Bayesian meta-analysis was conducted to synthesize evidence from eligible studies. Prospective survival studies of HIV-1-infected individuals, with outcome defined as time from baseline to all-cause death, were included and classified by whether GBV-C status was determined in early or late HIV disease. The primary measure was the hazard ratio (HR) of death for HIV-infected individuals with GBV-C infection versus those without GBV-C infection. RESULTS: Eleven studies from eight publications met the inclusion criteria. For studies with GBV-C status measured 2 years or less after HIV seroconversion (912 subjects), the combined HR was 0.88 [95% credible interval (CI) 0.30, 1.50]. For studies with GBV-C status measured more than 2 years after HIV seroconversion (1294 subjects), the combined HR was 0.41 (95% CI 0.23, 0.69). CONCLUSIONS: No conclusive evidence was found of an association between survival and GBV-C infection early in HIV disease. However, when GBV-C infection was present later in HIV disease, a significant reduction in the hazard for mortality was observed for those with co-infection. Potential explanations for this difference include a non-proportional benefit of GBV-C over time, possibly related to clearance of GBV-C infection early in HIV disease. The timing of GBV-C infection appears to account for the contradictory results of studies on the effect of GBV-C coinfection on survival of HIV-infected people.

Full Text

Cited Authors

  • Zhang, W; Chaloner, K; Tillmann, HL; Williams, CF; Stapleton, JT

Published Date

  • April 2006

Published In

Volume / Issue

  • 7 / 3

Start / End Page

  • 173 - 180

PubMed ID

  • 16494631

Pubmed Central ID

  • 16494631

International Standard Serial Number (ISSN)

  • 1464-2662

Digital Object Identifier (DOI)

  • 10.1111/j.1468-1293.2006.00366.x


  • eng

Conference Location

  • England