Persistence of occult hepatitis B after removal of the hepatitis B virus-infected liver.


Journal Article

Occult hepatitis B is defined as the persistence of hepatitis B virus (HBV) DNA in persons without HBV surface antigen (HBsAg). The primary site for HBV persistence in persons with occult hepatitis B is considered to be the liver. We provide virological and immunological evidence for long-term persistence of HBV, even after removal of the infected liver, in 25 consecutive, randomly selected liver transplant recipients who tested positive for anti-HBV core antigen (anti-HBcAg) and negative for HBsAg at the time of transplantation. Furthermore, in a cohort of 101 anti-HBcAg-positive/HBsAg-negative patients, 2 showed clinical HBV reactivation after transplantation. Thus, these data indicate that a long-term extrahepatic HBV reservoir exists, which is relevant not only for liver transplantation but also for other types of transplantations, including bone marrow grafting.

Full Text

Cited Authors

  • Ciesek, S; Helfritz, FA; Lehmann, U; Becker, T; Strassburg, CP; Neipp, M; Ciner, A; Fytili, P; Tillmann, HL; Manns, MP; Wedemeyer, H

Published Date

  • February 1, 2008

Published In

Volume / Issue

  • 197 / 3

Start / End Page

  • 355 - 360

PubMed ID

  • 18248299

Pubmed Central ID

  • 18248299

International Standard Serial Number (ISSN)

  • 0022-1899

Digital Object Identifier (DOI)

  • 10.1086/525286


  • eng

Conference Location

  • United States