GB virus C/hepatitis G virus infection: a favorable prognostic factor in human immunodeficiency virus-infected patients?


Journal Article

To investigate a possible influence of GB virus C (GBV-C) in immunocompromised patients, the prevalences of GBV-C RNA and anti-E2 antibody in 197 human immunodeficiency virus (HIV)-infected patients and in 120 control blood donors were studied. GBV-C RNA was detected in 33 of 197 HIV-infected patients (16.8%) compared with 1 in 120 blood donors (0.8%) (P < .001). Previous exposure to GBV-C (anti-E2 antibody-positive) was shown in 56.8% of HIV patients and in 9% of blood donors. GBV-C viremia was not associated with hepatitis. Despite approximately equal duration of HIV infection in all subgroups, the CD4 cell counts were significantly higher in GBV-C-viremic patients (344 cells/microL) compared with exposed (259 cells/microL) and unexposed (170 cells/microL) patients (P = .017 and P < .001). Furthermore, Kaplan-Meier analysis demonstrated significantly better cumulative survival in GBV-C RNA-positive HIV-infected patients, suggesting that GBV-C might be a favorable prognostic factor in HIV disease.

Full Text

Cited Authors

  • Heringlake, S; Ockenga, J; Tillmann, HL; Trautwein, C; Meissner, D; Stoll, M; Hunt, J; Jou, C; Solomon, N; Schmidt, RE; Manns, MP

Published Date

  • June 1998

Published In

Volume / Issue

  • 177 / 6

Start / End Page

  • 1723 - 1726

PubMed ID

  • 9607857

Pubmed Central ID

  • 9607857

International Standard Serial Number (ISSN)

  • 0022-1899

Digital Object Identifier (DOI)

  • 10.1086/517431


  • eng

Conference Location

  • United States