Efficacy of saline vs heparin in maintaining 24-gauge intermittent intravenous catheters in a rabbit model.

Journal Article (Journal Article)


The purpose of this study was to compare saline and heparin flushes in 24-gauge i.v. catheters.


A double-blind experiment in four recorded trials was conducted using a rabbit model. Twenty-four-gauge catheters were placed in both auricle veins, and all catheters were secured in the same manner. Ampicillin was infused into each ear at the same interval, with each ear randomized to receive either the heparin solution or the saline solution.


The subjects were ten white New Zealand rabbits. Data were collected on 76 catheter sites.

Main outcome variable

Patency for each catheter was measured in hours and evaluated based on presence of warmth, erythema, induration, leakage, or occlusion.


There was no significant difference in the duration of patency of the catheters between the two groups.

Full Text

Duke Authors

Cited Authors

  • Kyle, LA; Turner, BS

Published Date

  • September 1999

Published In

Volume / Issue

  • 18 / 6

Start / End Page

  • 49 - 54

PubMed ID

  • 10690098

Electronic International Standard Serial Number (EISSN)

  • 1539-2880

International Standard Serial Number (ISSN)

  • 0730-0832

Digital Object Identifier (DOI)

  • 10.1891/0730-0832.18.6.49


  • eng