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Cost-effectiveness of pharmacotherapies for nicotine dependence in primary care settings: a multinational comparison.

Publication ,  Journal Article
Cornuz, J; Gilbert, A; Pinget, C; McDonald, P; Slama, K; Salto, E; Paccaud, F
Published in: Tob Control
June 2006

OBJECTIVE: To estimate the incremental cost-effectiveness of the first-line pharmacotherapies (nicotine gum, patch, spray, inhaler, and bupropion) for smoking cessation across six Western countries-Canada, France, Spain, Switzerland, the United States, and the United Kingdom. DESIGN AND STUDY POPULATION: A Markov-chain cohort model to simulate two cohorts of smokers: (1) a reference cohort given brief cessation counselling by a general practitioner (GP); (2) a treatment cohort given counselling plus pharmacotherapy. Effectiveness expressed as odds ratios for quitting associated with pharmacotherapies. Costs based on the additional physician time required and retail prices of the medications. INTERVENTIONS: Addition of each first-line pharmacotherapy to GP cessation counselling. MAIN OUTCOME MEASURES: Cost per life-year saved associated with pharmacotherapies. RESULTS: The cost per life-year saved for counselling only ranged from US190 dollars in Spain to 773 dollars in the UK for men, and from 288 dollars in Spain to 1168 dollars in the UK for women. The incremental cost per life-year saved for gum ranged from 2230 dollars for men in Spain to 7643 dollars for women in the US; for patch from 1758 dollars for men in Spain to 5131 dollars for women in the UK; for spray from 1935 dollars for men in Spain to 7969 dollars for women in the US; for inhaler from 3480 dollars for men in Switzerland to 8700 dollars for women in France; and for bupropion from 792 dollars for men in Canada to 2922 dollars for women in the US. In sensitivity analysis, changes in discount rate, treatment effectiveness, and natural quit rate had the strongest influences on cost-effectiveness. CONCLUSIONS: The cost-effectiveness of the pharmacotherapies varied significantly across the six study countries, however, in each case, the results would be considered favourable as compared to other common preventive pharmacotherapies.

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Published In

Tob Control

DOI

EISSN

1468-3318

Publication Date

June 2006

Volume

15

Issue

3

Start / End Page

152 / 159

Location

England

Related Subject Headings

  • Treatment Outcome
  • Tobacco Use Disorder
  • Smoking Cessation
  • Sex Factors
  • Recurrence
  • Public Health
  • Primary Health Care
  • Nicotine
  • Middle Aged
  • Markov Chains
 

Citation

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ICMJE
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Cornuz, J., Gilbert, A., Pinget, C., McDonald, P., Slama, K., Salto, E., & Paccaud, F. (2006). Cost-effectiveness of pharmacotherapies for nicotine dependence in primary care settings: a multinational comparison. Tob Control, 15(3), 152–159. https://doi.org/10.1136/tc.2005.011551
Cornuz, J., A. Gilbert, C. Pinget, P. McDonald, K. Slama, E. Salto, and F. Paccaud. “Cost-effectiveness of pharmacotherapies for nicotine dependence in primary care settings: a multinational comparison.Tob Control 15, no. 3 (June 2006): 152–59. https://doi.org/10.1136/tc.2005.011551.
Cornuz J, Gilbert A, Pinget C, McDonald P, Slama K, Salto E, et al. Cost-effectiveness of pharmacotherapies for nicotine dependence in primary care settings: a multinational comparison. Tob Control. 2006 Jun;15(3):152–9.
Cornuz, J., et al. “Cost-effectiveness of pharmacotherapies for nicotine dependence in primary care settings: a multinational comparison.Tob Control, vol. 15, no. 3, June 2006, pp. 152–59. Pubmed, doi:10.1136/tc.2005.011551.
Cornuz J, Gilbert A, Pinget C, McDonald P, Slama K, Salto E, Paccaud F. Cost-effectiveness of pharmacotherapies for nicotine dependence in primary care settings: a multinational comparison. Tob Control. 2006 Jun;15(3):152–159.

Published In

Tob Control

DOI

EISSN

1468-3318

Publication Date

June 2006

Volume

15

Issue

3

Start / End Page

152 / 159

Location

England

Related Subject Headings

  • Treatment Outcome
  • Tobacco Use Disorder
  • Smoking Cessation
  • Sex Factors
  • Recurrence
  • Public Health
  • Primary Health Care
  • Nicotine
  • Middle Aged
  • Markov Chains