Diisopropyl phosphorofluoridate (DFP) treatment alters calcium-activated proteinase activity and cytoskeletal proteins of the hen sciatic nerve.


Journal Article

Diisopropyl phosphorofluoridate (DFP) produces delayed neurotoxicity (OPIDN) in hens that is characterized by peripheral and central axonal degeneration. DFP administration resulted in mCANP activity inhibition in sciatic nerve and significant decrease in total NF-H, phosphorylated NF-H, vimentin, GFAP, tubulin, and tau. The degradation of cytoskeletal proteins even in the presence of decreased CANP activity may be ascribed to the release of intracellular Ca2+, elevation of other proteinase activity, or modification of cytoskeletal proteins resulting in their increased susceptibility in OPIDN.

Full Text

Duke Authors

Cited Authors

  • Gupta, RP; Abou-Donia, MB

Published Date

  • April 17, 1995

Published In

Volume / Issue

  • 677 / 1

Start / End Page

  • 162 - 166

PubMed ID

  • 7606462

Pubmed Central ID

  • 7606462

International Standard Serial Number (ISSN)

  • 0006-8993

Digital Object Identifier (DOI)

  • 10.1016/0006-8993(95)00195-v


  • eng

Conference Location

  • Netherlands