Delayed neurotoxicity of phenylphosphonothioate esters.


Journal Article

Administration of a single oral dose of five phenylphosphonothioate esters produced delayed neurotoxicity in hens; their potency was, in descending order, cyanofenphos, EPN, desbromoleptophos, leptophos, and EPBP (Seven). Histological examination showed that in some hens there was marked axonal and myelin degeneration in the spinal cord and peripheral nerves. The results suggest that delayed neurotoxicity may be a general feature of phenylphosphonothioate insecticides.

Full Text

Duke Authors

Cited Authors

  • Abou-Donia, MB

Published Date

  • August 17, 1979

Published In

Volume / Issue

  • 205 / 4407

Start / End Page

  • 713 - 715

PubMed ID

  • 462181

Pubmed Central ID

  • 462181

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.462181


  • eng

Conference Location

  • United States