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The NEIGHBOR consortium primary open-angle glaucoma genome-wide association study: rationale, study design, and clinical variables.

Publication ,  Journal Article
Wiggs, JL; Hauser, MA; Abdrabou, W; Allingham, RR; Budenz, DL; Delbono, E; Friedman, DS; Kang, JH; Gaasterland, D; Gaasterland, T; Lee, RK ...
Published in: J Glaucoma
September 2013

Primary open-angle glaucoma (POAG) is a common disease with complex inheritance. The identification of genes predisposing to POAG is an important step toward the development of novel gene-based methods of diagnosis and treatment. Genome-wide association studies (GWAS) have successfully identified genes contributing to complex traits such as POAG however, such studies frequently require very large sample sizes, and thus, collaborations and consortia have been of critical importance for the GWAS approach. In this report we describe the formation of the NEIGHBOR consortium, the harmonized case control definitions used for a POAG GWAS, the clinical features of the cases and controls, and the rationale for the GWAS study design.

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Published In

J Glaucoma

DOI

EISSN

1536-481X

Publication Date

September 2013

Volume

22

Issue

7

Start / End Page

517 / 525

Location

United States

Related Subject Headings

  • Trabeculectomy
  • Research Design
  • Ophthalmology & Optometry
  • Middle Aged
  • Male
  • Intraocular Pressure
  • Humans
  • Glaucoma, Open-Angle
  • Genotype
  • Genome-Wide Association Study
 

Citation

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Wiggs, J. L., Hauser, M. A., Abdrabou, W., Allingham, R. R., Budenz, D. L., Delbono, E., … Haines, J. L. (2013). The NEIGHBOR consortium primary open-angle glaucoma genome-wide association study: rationale, study design, and clinical variables. J Glaucoma, 22(7), 517–525. https://doi.org/10.1097/IJG.0b013e31824d4fd8
Wiggs, Janey L., Michael A. Hauser, Wael Abdrabou, Robert Rand Allingham, Donald L. Budenz, Elizabeth Delbono, David S. Friedman, et al. “The NEIGHBOR consortium primary open-angle glaucoma genome-wide association study: rationale, study design, and clinical variables.J Glaucoma 22, no. 7 (September 2013): 517–25. https://doi.org/10.1097/IJG.0b013e31824d4fd8.
Wiggs JL, Hauser MA, Abdrabou W, Allingham RR, Budenz DL, Delbono E, et al. The NEIGHBOR consortium primary open-angle glaucoma genome-wide association study: rationale, study design, and clinical variables. J Glaucoma. 2013 Sep;22(7):517–25.
Wiggs, Janey L., et al. “The NEIGHBOR consortium primary open-angle glaucoma genome-wide association study: rationale, study design, and clinical variables.J Glaucoma, vol. 22, no. 7, Sept. 2013, pp. 517–25. Pubmed, doi:10.1097/IJG.0b013e31824d4fd8.
Wiggs JL, Hauser MA, Abdrabou W, Allingham RR, Budenz DL, Delbono E, Friedman DS, Kang JH, Gaasterland D, Gaasterland T, Lee RK, Lichter PR, Loomis S, Liu Y, McCarty C, Medeiros FA, Moroi SE, Olson LM, Realini A, Richards JE, Rozsa FW, Schuman JS, Singh K, Stein JD, Vollrath D, Weinreb RN, Wollstein G, Yaspan BL, Yoneyama S, Zack D, Zhang K, Pericak-Vance M, Pasquale LR, Haines JL. The NEIGHBOR consortium primary open-angle glaucoma genome-wide association study: rationale, study design, and clinical variables. J Glaucoma. 2013 Sep;22(7):517–525.

Published In

J Glaucoma

DOI

EISSN

1536-481X

Publication Date

September 2013

Volume

22

Issue

7

Start / End Page

517 / 525

Location

United States

Related Subject Headings

  • Trabeculectomy
  • Research Design
  • Ophthalmology & Optometry
  • Middle Aged
  • Male
  • Intraocular Pressure
  • Humans
  • Glaucoma, Open-Angle
  • Genotype
  • Genome-Wide Association Study