Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene.
Journal Article (Journal Article)
Although disorders of iron metabolism are prevalent, iron transport remains poorly understood. To address this problem, we undertook a positional cloning strategy to identify the causative mutation in mice with microcytic anaemia (mk). Homozygous mk/mk mice have microcytic, hypochromic anaemia due to severe defects in intestinal iron absorption and erythroid iron utilization. We report the identification of a strong candidate gene for mk, and suggest that the phenotype is a consequence of a missense mutation in Nramp2 (ref. 5), a previously identified gene of unknown function. Nramp2 is homologous to Nramp1, a gene activa in host defense. If Nramp2 is mk, as the cumulative evidence suggests, our findings have broad implications for the understanding of iron transport and resistance to intracellular pathogens.
- Fleming, MD; Trenor, CC; Su, MA; Foernzler, D; Beier, DR; Dietrich, WF; Andrews, NC
- August 1997
Volume / Issue
- 16 / 4
Start / End Page
- 383 - 386
International Standard Serial Number (ISSN)
Digital Object Identifier (DOI)
- United States