Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene.

Journal Article (Journal Article)

Although disorders of iron metabolism are prevalent, iron transport remains poorly understood. To address this problem, we undertook a positional cloning strategy to identify the causative mutation in mice with microcytic anaemia (mk). Homozygous mk/mk mice have microcytic, hypochromic anaemia due to severe defects in intestinal iron absorption and erythroid iron utilization. We report the identification of a strong candidate gene for mk, and suggest that the phenotype is a consequence of a missense mutation in Nramp2 (ref. 5), a previously identified gene of unknown function. Nramp2 is homologous to Nramp1, a gene activa in host defense. If Nramp2 is mk, as the cumulative evidence suggests, our findings have broad implications for the understanding of iron transport and resistance to intracellular pathogens.

Full Text

Duke Authors

Cited Authors

  • Fleming, MD; Trenor, CC; Su, MA; Foernzler, D; Beier, DR; Dietrich, WF; Andrews, NC

Published Date

  • August 1997

Published In

Volume / Issue

  • 16 / 4

Start / End Page

  • 383 - 386

PubMed ID

  • 9241278

International Standard Serial Number (ISSN)

  • 1061-4036

Digital Object Identifier (DOI)

  • 10.1038/ng0897-383


  • eng

Conference Location

  • United States