Contrast echocardiography: a method to visualize changes in regional myocardial perfusion in the dog model for CABG surgery.


Journal Article

The ability of contrast echocardiography to assess regional myocardial perfusion during cardiopulmonary bypass in a dog model for coronary artery bypass surgery was evaluated. Sonicated Renograffin-76 microbubbles (meglumin diatrigoate and sodium diatrigoate) were injected into an aortic root proximal to an aortic occlusion clamp root while dogs were on cardiopulmonary bypass, with the heart arrested in diastole. Echocardiographic contrast-enhanced regions of myocardial perfusion were easily visualized. Differences in contrast-enhanced myocardial regions depended on coronary artery occlusion or patency. The contrast-enhanced images of myocardial perfusion showed that, for a given myocardial segment of the supplying vessel, the presence or absence of contrast effect reliably predicted vessel occlusion or patency (P less than .01). In the future contrast echocardiography may allow the direct assessment of regional myocardial perfusion in the operating room.

Full Text

Duke Authors

Cited Authors

  • Aronson, S; Bender, E; Feinstein, SB; Heidenreich, PH; Ellis, J; Dick, C; Roizen, MF; Karp, RB

Published Date

  • February 1990

Published In

Volume / Issue

  • 72 / 2

Start / End Page

  • 295 - 301

PubMed ID

  • 2301760

Pubmed Central ID

  • 2301760

International Standard Serial Number (ISSN)

  • 0003-3022


  • eng

Conference Location

  • United States