Syntheses and superoxide dismuting activities of partially (1-4) β-chlorinated derivatives of manganese(III) meso-tetrakis(N-ethylpyridinium-2-yl)porphyrin

Published

Journal Article

Manganese(III) β-mono-, di-, tri-, and tetrachloro-5,10,15,20-tetrakis(N-ethylpyridinium-2-yl)porphyrin (MnClx-TE-2-PyP5+, with x from 1 to 4) were prepared through β-chlorination of 5,10,15,20-tetrakis(2-pyridyl)porphyrin (H2T-2-PyP) followed by N-ethylation and metallation. Metal centered redox potentials and superoxide dismutation activities were measured. Starting from MnTE-2-PyP5+, whose redox potential and the related superoxide dismutation activity were E°1/2 = +228 mV vs NHE and kcat = 5.7 × 107 M-1 s-1, respectively, the average increase of 55 mV in the redox potential per added chlorine was accompanied by a 65% increase in the rate constant. With E°1/2 = +448 mV, the tetrachlorinated derivative MnCl4TE-2-PyP5+ exhibited the highest superoxide dismuting rate kcat = 4.0 × 108 M-1 s-1. The relationship between the redox properties (thermodynamic and kinetic factors) and the superoxide dismuting activity of such compounds is discussed. © 1999 American Chemical Society.

Duke Authors

Cited Authors

  • Kachadourian, R; Batinić-Haberle, I; Fridovich, I

Published Date

  • December 1, 1999

Published In

Volume / Issue

  • 38 / 2

Start / End Page

  • 391 - 396

International Standard Serial Number (ISSN)

  • 0020-1669

Citation Source

  • Scopus