Platelet activation and its patient-specific consequences.

Published

Journal Article (Review)

Individuals vary in their thrombotic response to vascular injury. The reasons for this are numerous, involving heterogeneity in multiple platelet responses. Platelet research has tended to focus on functioning at the molecular level, and many experiments reflect results obtained in isolated, in vitro systems. However, platelets function in a complex and dynamic in vivo environment with the potential for a wide range of biological influences. This article reviews the evidence for diversity in platelet responses and the implications for individual variability in propensity to arterial thrombosis. Three overarching phenomena are considered. First, platelets can vary quantitatively and qualitatively in their responses to agonists. Second, platelets appear to have different intrinsic levels of procoagulant activity. Third, responses to various procoagulant, regulatory, and mediating factors likewise differ within and among individuals and can be influenced by blood-borne factors. These phenomena may help to explain differences in experimental arterial thrombosis observed in individuals.

Full Text

Duke Authors

Cited Authors

  • Smyth, SS; Monroe, DM; Wysokinski, WE; McBane, RD; Whiteheart, SW; Becker, RC; Steinhubl, SR

Published Date

  • 2008

Published In

Volume / Issue

  • 122 / 4

Start / End Page

  • 435 - 441

PubMed ID

  • 17949794

Pubmed Central ID

  • 17949794

International Standard Serial Number (ISSN)

  • 0049-3848

Digital Object Identifier (DOI)

  • 10.1016/j.thromres.2007.08.023

Language

  • eng

Conference Location

  • United States