Improving the efficacy and stability of coronary reperfusion following thrombolysis: Exploring the thrombin hypothesis

Journal Article

A major assumption in the treatment of patients with acute myocardial infarction (MI) implies that the speed of coronary arterial reperfusion correlates directly with the overall extent of myocardial salvage, and that the extent of myocardial salvage, in turn, determines the absolute reduction in patient mortality. While a growing experience has made it clear that myocardial salvage-independent (time-independent) mechanisms of benefit also exist, few would argue with the hypothesis that the greatest benefit derived from coronary thrombolysis occurs with early (time-dependent) treatment. Thus, improvements in the efficacy of reperfusion and the stability of reperfusion are likely to have considerable impact on patient outcome. © 1995 Kluwer Academic Publishers.

Full Text

Duke Authors

Cited Authors

  • Becker, RC

Published Date

  • 1995

Published In

Volume / Issue

  • 1 / 2

Start / End Page

  • 133 - 144

International Standard Serial Number (ISSN)

  • 0929-5305

Digital Object Identifier (DOI)

  • 10.1007/BF01062570