Expanding the paradigm of the renin-angiotensin system and angiotensin-converting enzyme inhibitors

Journal Article

The renin-angiotensin system acts systemically and locally to influence vascular tone, blood volume, myocardial contractility, thromboresistance, and tissue responses to injury. ACE inhibitors have assumed a vital role in the treatment of patients with ventricular dysfunction, including those who have sustained one or more myocardial infarctions. The greatest benefits appear over time and not unexpectedly are most pronounced in cases of moderate to severe reduction in left ventricular performance. Emerging evidence suggests that the paradigm for ACE inhibitor use will expand even further, opening new doors for patient care. © 1994.

Full Text

Duke Authors

Cited Authors

  • Greenwald, L; Becker, RC

Published Date

  • 1994

Published In

Volume / Issue

  • 128 / 5

Start / End Page

  • 997 - 1009

International Standard Serial Number (ISSN)

  • 0002-8703

Digital Object Identifier (DOI)

  • 10.1016/0002-8703(94)90600-9