The mast cell-specific expression of a protease gene, RMCP II, is regulated by an enhancer element that binds specifically to mast cell trans-acting factors.

Journal Article

The rat mast cell protease gene, RMCP II, is specifically expressed in the mucosal subclass of rat mast cells. We show here that the 5'-flanking region of this gene contains a mast cell-specific enhancer that directs preferential expression of a linked reporter gene (human growth hormone) transfected into rat basophilic leukemia cells. A DNA fragment containing the enhancer sequence is capable of binding specifically to mast cell nuclear trans-acting factors. The sequence of this enhancer element contains a region of homology to a consensus core sequence present in the enhancer region of the pancreatic protease genes.

Full Text

Duke Authors

Cited Authors

  • Sarid, J; Benfey, PN; Leder, P

Published Date

  • January 15, 1989

Published In

Volume / Issue

  • 264 / 2

Start / End Page

  • 1022 - 1026

PubMed ID

  • 2642895

International Standard Serial Number (ISSN)

  • 0021-9258

Language

  • eng

Conference Location

  • United States