Human and rat mast cell high-affinity immunoglobulin E receptors: characterization of putative alpha-chain gene products.


Journal Article

We have cloned and determined the entire nucleotide sequence of cDNAs corresponding to the putative alpha subunits of the human and rat mast cell high-affinity IgE receptors. Both human and rat cDNAs encode an NH2-terminal signal peptide, two immunoglobulin-like extracellular domains (encoded by discrete exons), a hydrophobic transmembrane region, and a positively charged cytoplasmic tail. The human and rat alpha subunits share an overall homology with one another and the immunoglobulin gene family, suggesting that they arose from a common ancestral gene and continue to share structural homology with their ligands. In addition, the rat gene is transcribed into at least three distinct forms, each of which yields a somewhat different coding sequence.

Full Text

Duke Authors

Cited Authors

  • Shimizu, A; Tepler, I; Benfey, PN; Berenstein, EH; Siraganian, RP; Leder, P

Published Date

  • March 1988

Published In

Volume / Issue

  • 85 / 6

Start / End Page

  • 1907 - 1911

PubMed ID

  • 2964640

Pubmed Central ID

  • 2964640

Electronic International Standard Serial Number (EISSN)

  • 1091-6490

International Standard Serial Number (ISSN)

  • 0027-8424

Digital Object Identifier (DOI)

  • 10.1073/pnas.85.6.1907


  • eng