Human and rat mast cell high-affinity immunoglobulin E receptors: characterization of putative alpha-chain gene products.
Journal Article (Journal Article)
We have cloned and determined the entire nucleotide sequence of cDNAs corresponding to the putative alpha subunits of the human and rat mast cell high-affinity IgE receptors. Both human and rat cDNAs encode an NH2-terminal signal peptide, two immunoglobulin-like extracellular domains (encoded by discrete exons), a hydrophobic transmembrane region, and a positively charged cytoplasmic tail. The human and rat alpha subunits share an overall homology with one another and the immunoglobulin gene family, suggesting that they arose from a common ancestral gene and continue to share structural homology with their ligands. In addition, the rat gene is transcribed into at least three distinct forms, each of which yields a somewhat different coding sequence.
Full Text
Duke Authors
Cited Authors
- Shimizu, A; Tepler, I; Benfey, PN; Berenstein, EH; Siraganian, RP; Leder, P
Published Date
- March 1988
Published In
Volume / Issue
- 85 / 6
Start / End Page
- 1907 - 1911
PubMed ID
- 2964640
Pubmed Central ID
- PMC279890
Electronic International Standard Serial Number (EISSN)
- 1091-6490
International Standard Serial Number (ISSN)
- 0027-8424
Digital Object Identifier (DOI)
- 10.1073/pnas.85.6.1907
Language
- eng