Human and rat mast cell high-affinity immunoglobulin E receptors: characterization of putative alpha-chain gene products.

Journal Article (Journal Article)

We have cloned and determined the entire nucleotide sequence of cDNAs corresponding to the putative alpha subunits of the human and rat mast cell high-affinity IgE receptors. Both human and rat cDNAs encode an NH2-terminal signal peptide, two immunoglobulin-like extracellular domains (encoded by discrete exons), a hydrophobic transmembrane region, and a positively charged cytoplasmic tail. The human and rat alpha subunits share an overall homology with one another and the immunoglobulin gene family, suggesting that they arose from a common ancestral gene and continue to share structural homology with their ligands. In addition, the rat gene is transcribed into at least three distinct forms, each of which yields a somewhat different coding sequence.

Full Text

Duke Authors

Cited Authors

  • Shimizu, A; Tepler, I; Benfey, PN; Berenstein, EH; Siraganian, RP; Leder, P

Published Date

  • March 1988

Published In

Volume / Issue

  • 85 / 6

Start / End Page

  • 1907 - 1911

PubMed ID

  • 2964640

Pubmed Central ID

  • PMC279890

Electronic International Standard Serial Number (EISSN)

  • 1091-6490

International Standard Serial Number (ISSN)

  • 0027-8424

Digital Object Identifier (DOI)

  • 10.1073/pnas.85.6.1907


  • eng