Growth regulation and transformation of ovarian epithelium


Journal Article

The discovery of peptide growth factors and cancer‐causing genes (oncogenes and tumor‐suppressor genes) has provided us with the exciting opportunity to begin to understand the molecular pathology of human ovarian cancer. Activation of several genes, including HER‐2/neu, myc, ras, and p53 have been described in some ovarian cancers. In addition, some protooncogenes such as the epidermal growth factor receptor (erbB) and the MCSF receptor (fms) are expressed along with their respective ligands (peptide growth factors) in some ovarian cancers. Although the studies reviewed in this paper represent a promising beginning, we remain far from a comprehensive understanding of growth regulation and transformation of human ovarian epithelium. Copyright © 1993 American Cancer Society

Full Text

Duke Authors

Cited Authors

  • Berchuck, A; Kohler, MF; Boente, MP; Rodriguez, GC; Whitaker, RS; Bast, RC

Published Date

  • January 1, 1993

Published In

Volume / Issue

  • 71 / 2 S

Start / End Page

  • 545 - 551

Electronic International Standard Serial Number (EISSN)

  • 1097-0142

International Standard Serial Number (ISSN)

  • 0008-543X

Digital Object Identifier (DOI)

  • 10.1002/cncr.2820710209

Citation Source

  • Scopus