Immunobiology of primary intracranial tumors. Part 2: The evaluation of chemotherapy and immunotherapy protocols using the avian sarcoma virus glioma model

Journal Article

The avian sarcoma virus-induced glioma model in rats was used to study the effectiveness of immunotherapy, namely, Bacillus Calmette-Guerin (BCG) with or without sarcoma cells and/or chemotherapy with 1,3-bis (2-chloroethyl)-1-nitrosourea (BCNU), upon survival times. The most consistent prolongation of survival time was produced by triple therapy: BCG + intraperitoneally administered sarcoma cells + intravenously administered BCNU.

Duke Authors

Cited Authors

  • Jr, MSM; Gentry, RE; Bigner, DD

Published Date

  • 1977

Published In

  • Journal of Neurosurgery

Volume / Issue

  • 47 / 1

Start / End Page

  • 35 - 43