Crystal structure of O4-methyl uridine: stacking induced changes in the geometry of the pyrimidine ring and its mutagenic role.

Journal Article (Journal Article)

The geometric properties of the pyrimidine ring of O4-methyl uridine more closely resemble those of cytidine than diketo uridine. Differences between the independent molecules of O4-methyl uridine are observed in the C(7)-O(4)-C(4)-C(5)-C(6) bond orders and the planarity of the pyrimidine rings. These differences are attributed to the monopole-induced dipole interactions between the ribose ring oxygen atom and a neighboring base of molecule A. A survey of the literature reveals that similar stacking-induced effects occur in other structures, involving both pyrimidine and purines. Finally, two base pairing schemes between O4-methyl uridine and guanosine, in which two hydrogen bonds can form, have been presented. Of these two the mispair with Watson-Crick geometry is favored.

Full Text

Duke Authors

Cited Authors

  • Brennan, RG; Privé, GG; Blonski, WJ; Hruska, FE; Sundaralingam, M

Published Date

  • December 1, 1983

Published In

Volume / Issue

  • 1 / 4

Start / End Page

  • 939 - 945

PubMed ID

  • 6400906

International Standard Serial Number (ISSN)

  • 0739-1102

Digital Object Identifier (DOI)

  • 10.1080/07391102.1983.10507495


  • eng

Conference Location

  • England