Genetic and genomic approaches to reward and addiction.


Journal Article (Review)

Drug addiction is recognized as a mental disease affecting the brain's natural reward system. Drugs of abuse strongly activate reward structures in the brain and induce lasting changes in behavior that reflect changes in neuron physiology and biochemistry. With the ultimate goal of developing therapeutic interventions, it is of interest to determine the molecular and cellular components of motivation and reward, and identify those gene products that contribute to the process of drug addiction. Our laboratory has chosen three general genetic approaches to examine reward and addiction: reverse genetics to assess the role of candidate genes in drug responsiveness, forward genetics to discover novel regulators of dopamine transmission, and gene expression profiling to define gene sets in different brain structures that contribute to the molecular and neurobiological basis of reward.

Full Text

Duke Authors

Cited Authors

  • Mohn, AR; Yao, W-D; Caron, MG

Published Date

  • 2004

Published In

Volume / Issue

  • 47 Suppl 1 /

Start / End Page

  • 101 - 110

PubMed ID

  • 15464129

Pubmed Central ID

  • 15464129

International Standard Serial Number (ISSN)

  • 0028-3908

Digital Object Identifier (DOI)

  • 10.1016/j.neuropharm.2004.07.025


  • eng

Conference Location

  • England