A molecular basis for MHC class II--associated autoimmunity.

Published

Journal Article

Class II major histocompatibility (MHC) molecules have an immunoregulatory role. These cell-surface glycoproteins present fragments of protein antigens (or peptides) to thymus-derived lymphocytes (T cells). Nucleotide sequence polymorphism in the genes that encode the class II MHC products determines the specificity of the immune response and is correlated with the development of autoimmune diseases. This study identifies certain class II polymorphic amino acid residues that are strongly associated with susceptibility to insulin-dependent diabetes mellitus, rheumatoid arthritis, and pemphigus vulgaris. These findings implicate particular class II MHC isotypes in susceptibility to each disease and suggest new prophylactic and therapeutic strategies.

Full Text

Duke Authors

Cited Authors

  • Todd, JA; Acha-Orbea, H; Bell, JI; Chao, N; Fronek, Z; Jacob, CO; McDermott, M; Sinha, AA; Timmerman, L; Steinman, L

Published Date

  • May 20, 1988

Published In

Volume / Issue

  • 240 / 4855

Start / End Page

  • 1003 - 1009

PubMed ID

  • 3368786

Pubmed Central ID

  • 3368786

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.3368786

Language

  • eng

Conference Location

  • United States