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Pharmacogenomics of adverse drug reactions: implementing personalized medicine.

Publication ,  Journal Article
Wei, C-Y; Lee, M-TM; Chen, Y-T
Published in: Hum Mol Genet
October 15, 2012

Pharmacogenomics aims to investigate the genetic basis of inter-individual differences in drug responses, such as efficacy, dose requirements and adverse events. Research in pharmacogenomics has grown over the past decade, evolving from a candidate-gene approach to genome-wide association studies (GWASs). Genetic variants in genes coding for drug metabolism, drug transport and more recently human-leukocyte antigens (HLAs) have been linked to inter-individual differences in the risk of adverse drug reactions (ADRs). The tight association of specific HLA alleles with Stevens-Johnson syndrome, toxic epidermal necrolysis, drug hypersensitivity syndrome and drug-induced liver injury underscore the importance of HLA in the pathogenesis of these idiosyncratic drug hypersensitivity reactions. However, as with the search for the genetic basis for common diseases, pharmacogenomic research, including GWAS, has so far been a disappointment in discovering major gene variants responsible for the efficacy of drugs used to treat common diseases. This review focuses on the pharmacogenomics of ADRs, the underlying mechanisms and the potential use of genomic biomarkers in clinical practice for dose adjustment and the avoidance of drug toxicity. We also discuss obstacles to the implementation of pharmacogenomics and the direction of future translational research.

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Published In

Hum Mol Genet

DOI

EISSN

1460-2083

Publication Date

October 15, 2012

Volume

21

Issue

R1

Start / End Page

R58 / R65

Location

England

Related Subject Headings

  • Precision Medicine
  • Pharmacogenetics
  • Inactivation, Metabolic
  • Humans
  • HLA Antigens
  • Genetics & Heredity
  • Genetic Variation
  • Genetic Markers
  • Drug-Related Side Effects and Adverse Reactions
  • Drug Hypersensitivity
 

Citation

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Wei, C.-Y., Lee, M.-T., & Chen, Y.-T. (2012). Pharmacogenomics of adverse drug reactions: implementing personalized medicine. Hum Mol Genet, 21(R1), R58–R65. https://doi.org/10.1093/hmg/dds341
Wei, Chun-Yu, Ming-Ta Michael Lee, and Yuan-Tsong Chen. “Pharmacogenomics of adverse drug reactions: implementing personalized medicine.Hum Mol Genet 21, no. R1 (October 15, 2012): R58–65. https://doi.org/10.1093/hmg/dds341.
Wei C-Y, Lee M-TM, Chen Y-T. Pharmacogenomics of adverse drug reactions: implementing personalized medicine. Hum Mol Genet. 2012 Oct 15;21(R1):R58–65.
Wei, Chun-Yu, et al. “Pharmacogenomics of adverse drug reactions: implementing personalized medicine.Hum Mol Genet, vol. 21, no. R1, Oct. 2012, pp. R58–65. Pubmed, doi:10.1093/hmg/dds341.
Wei C-Y, Lee M-TM, Chen Y-T. Pharmacogenomics of adverse drug reactions: implementing personalized medicine. Hum Mol Genet. 2012 Oct 15;21(R1):R58–R65.
Journal cover image

Published In

Hum Mol Genet

DOI

EISSN

1460-2083

Publication Date

October 15, 2012

Volume

21

Issue

R1

Start / End Page

R58 / R65

Location

England

Related Subject Headings

  • Precision Medicine
  • Pharmacogenetics
  • Inactivation, Metabolic
  • Humans
  • HLA Antigens
  • Genetics & Heredity
  • Genetic Variation
  • Genetic Markers
  • Drug-Related Side Effects and Adverse Reactions
  • Drug Hypersensitivity