Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations.
Chronic kidney disease (CKD), impairment of kidney function, is a serious public health problem, and the assessment of genetic factors influencing kidney function has substantial clinical relevance. Here, we report a meta-analysis of genome-wide association studies for kidney function-related traits, including 71,149 east Asian individuals from 18 studies in 11 population-, hospital- or family-based cohorts, conducted as part of the Asian Genetic Epidemiology Network (AGEN). Our meta-analysis identified 17 loci newly associated with kidney function-related traits, including the concentrations of blood urea nitrogen, uric acid and serum creatinine and estimated glomerular filtration rate based on serum creatinine levels (eGFRcrea) (P < 5.0 × 10(-8)). We further examined these loci with in silico replication in individuals of European ancestry from the KidneyGen, CKDGen and GUGC consortia, including a combined total of ∼110,347 individuals. We identify pleiotropic associations among these loci with kidney function-related traits and risk of CKD. These findings provide new insights into the genetics of kidney function.
Okada, Y; Sim, X; Go, MJ; Wu, J-Y; Gu, D; Takeuchi, F; Takahashi, A; Maeda, S; Tsunoda, T; Chen, P; Lim, S-C; Wong, T-Y; Liu, J; Young, TL; Aung, T; Seielstad, M; Teo, Y-Y; Kim, YJ; Lee, J-Y; Han, B-G; Kang, D; Chen, C-H; Tsai, F-J; Chang, L-C; Fann, S-JC; Mei, H; Rao, DC; Hixson, JE; Chen, S; Katsuya, T; Isono, M; Ogihara, T; Chambers, JC; Zhang, W; Kooner, JS; KidneyGen Consortium, ; CKDGen Consortium, ; Albrecht, E; GUGC consortium, ; Yamamoto, K; Kubo, M; Nakamura, Y; Kamatani, N; Kato, N; He, J; Chen, Y-T; Cho, YS; Tai, E-S; Tanaka, T
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