Vitamins E and K induce aryl hydrocarbon hydroxylase activity in human cell cultures.

Journal Article (Journal Article)

Two fat soluble vitamins, Vitamins E and K, when added into culture medium, were found to increase aryl hydrocarbon hydroxylase activity in human cultured cells. The extent of induction in a hepatoma-derived cell line (Hep G2) by these vitamins is of similar magnitude to those cells receiving benz[a]anthracene; whereas in a mammary tumor-derived cell line (MCF-7), benz[a]anthracene is the best inducer for the hydroxylase activity. The increase of the hydroxylase activity is associated with increased levels of a specific mRNA coding for polynuclear aromatic hydrocarbons-induced form of cytochrome P-450 with Vitamins E and K treatment. The size of the induced mRNA is 3.3 kilobase which is the same as that of benz[a]anthracene treatment.

Full Text

Duke Authors

Cited Authors

  • Chen, YT; Ding, JH

Published Date

  • March 30, 1987

Published In

Volume / Issue

  • 143 / 3

Start / End Page

  • 863 - 871

PubMed ID

  • 3032186

International Standard Serial Number (ISSN)

  • 0006-291X

Digital Object Identifier (DOI)

  • 10.1016/0006-291x(87)90329-9


  • eng

Conference Location

  • United States