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Resistance of the male gonad to a high galactose diet.

Publication ,  Journal Article
Chen, YT; Mattison, DR; Bercu, BB; Schulman, JD
Published in: Pediatr Res
April 1984

Rats were fed a 50% galactose diet during pregnancy and nursing, and the testes were later examined and hormone levels determined in male offspring. Exposure to galactose for various periods during pregnancy, throughout the entire gestation, or postnatally to nursing mother until pups were 5 wk of age produced no significant differences from control testicular weight, seminiferous tubular diameter, or microscopic appearance of the testis when the offspring became adult (66 or 127 d). Serum luteinizing hormone, follicle stimulating hormone, and testosterone levels were determined 127 d postnatally and no significant differences from controls were observed in any of the treatment groups. Blood galactose-1-phosphate levels in animals receiving the 50% galactose diet were comparable to levels observed in human galactosemia. The resistance of the rat testis to a high galactose diet is consistent with the infrequency of testicular insufficiency in human galactosemia, and contrasts with the prenatal female gonadal sensitivity to galactose previously demonstrated in the rat and the high frequency of ovarian failure in human galactosemia.

Duke Scholars

Published In

Pediatr Res

DOI

ISSN

0031-3998

Publication Date

April 1984

Volume

18

Issue

4

Start / End Page

345 / 348

Location

United States

Related Subject Headings

  • Testosterone
  • Testis
  • Rats, Inbred Strains
  • Rats
  • Pregnancy
  • Pediatrics
  • Ovary
  • Organ Size
  • Male
  • Gonadotropins
 

Citation

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Chen, Y. T., Mattison, D. R., Bercu, B. B., & Schulman, J. D. (1984). Resistance of the male gonad to a high galactose diet. Pediatr Res, 18(4), 345–348. https://doi.org/10.1203/00006450-198404000-00008
Chen, Y. T., D. R. Mattison, B. B. Bercu, and J. D. Schulman. “Resistance of the male gonad to a high galactose diet.Pediatr Res 18, no. 4 (April 1984): 345–48. https://doi.org/10.1203/00006450-198404000-00008.
Chen YT, Mattison DR, Bercu BB, Schulman JD. Resistance of the male gonad to a high galactose diet. Pediatr Res. 1984 Apr;18(4):345–8.
Chen, Y. T., et al. “Resistance of the male gonad to a high galactose diet.Pediatr Res, vol. 18, no. 4, Apr. 1984, pp. 345–48. Pubmed, doi:10.1203/00006450-198404000-00008.
Chen YT, Mattison DR, Bercu BB, Schulman JD. Resistance of the male gonad to a high galactose diet. Pediatr Res. 1984 Apr;18(4):345–348.

Published In

Pediatr Res

DOI

ISSN

0031-3998

Publication Date

April 1984

Volume

18

Issue

4

Start / End Page

345 / 348

Location

United States

Related Subject Headings

  • Testosterone
  • Testis
  • Rats, Inbred Strains
  • Rats
  • Pregnancy
  • Pediatrics
  • Ovary
  • Organ Size
  • Male
  • Gonadotropins