Reduction in oocyte number following prenatal exposure to a diet high in galactose.

Journal Article (Journal Article)

When pregnant rats were fed a 50 percent galactose diet there was a striking reduction in oocyte number in the offspring. The most prominent effects were noted after exposure to galactose during the premeiotic stages of oogenesis. Prenatal exposure to galactose or its metabolites may contribute to the premature ovarian failure characteristic of human galactosemia.

Full Text

Duke Authors

Cited Authors

  • Chen, YT; Mattison, DR; Feigenbaum, L; Fukui, H; Schulman, JD

Published Date

  • December 4, 1981

Published In

Volume / Issue

  • 214 / 4525

Start / End Page

  • 1145 - 1147

PubMed ID

  • 7302587

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.7302587


  • eng

Conference Location

  • United States