Conjugates of Stimuli-Responsive Polymers and Biomolecules: Random and Site-Specific Conjugates of Temperature-Sensitive Polymers and Proteins


Journal Article

Intelligent polymers exhibit sharp, reversible phase changes in response to small changes in environmental conditions. For example, a small temperature change can cause a sharp precipitation or gelation of a smart polymer solution. Conjugation of these unusual polymers to biomolecules such as enzymes, ligands, lipids, and drugs can lead to many new and exciting applications in medicine and biotechnology. (1-4) This presentation reviews the principles, methodolgies and applications of these "smart" polymer-biomolecule systems, with special focus on temperature-sensitive polymer-protein conjugates.

Full Text

Duke Authors

Cited Authors

  • Hoffman, AS; Stayton, PS; Shimoboji, T; Chen, G; Ding, Z; Chilkoti, A; Long, C; Miura, M; Chen, J; Park, T; Monji, N; Cole, CA; Harris, JM; Nakamae, K

Published Date

  • January 1, 1997

Published In

Volume / Issue

  • 118 /

Start / End Page

  • 553 - 562

International Standard Serial Number (ISSN)

  • 1022-1360

Digital Object Identifier (DOI)

  • 10.1002/masy.19971180173

Citation Source

  • Scopus